Protein Details: Potassium channel subfamily K member 7

Protein ID

ICDB_Pro_1714

Protein Name

Potassium channel subfamily K member 7

Gene Name

KCNK7

Organism

Homo sapiens (Human)

Length

307 amino acids

AlphaFoldDB

AF-Q9Y2U2-F1-model_v4.pdb

Function

Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.

Sequence

MGGLRPWSRYGLLVVAHLLALGLGAVVFQALEGPPACRLQAELRAELAAFQAEHRACLPPGALEELLGTALATQAHGVSTLGNSSEGRTWDLPSALLFAASILTTTGYGHMAPLSPGGKAFCMVYAALGLPASLALVATLRHCLLPVLSRPRAWVAVHWQLSPARAALLQAVALGLLVASSFVLLPALVLWGLQGDCSLLGAVYFCFSSLSTIGLEDLLPGRGRSLHPVIYHLGQLALLGYLLLGLLAMLLAVETFSELPQVRAMGKFFRPSGPVTAEDQGGILGQDELALSTLPPAAPASGQAPAC

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Birk-Barel Syndrome and Bardet-Biedl Syndrome 22

Location

DOI ID

10.1074/jbc.274.17.11751; 10.1101/gr.2596504

RefSeq

NP_005705.1 [Q9Y2U2-3]; NP_203133.1 [Q9Y2U2-1]; NP_203134.1 [Q9Y2U2-2]; NP_258416.1 [Q9Y2U2-2];